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Muscle loss appears proportional to aging, disease condition and the degree of weight loss achieved

Persistently elevated concentrations of CRP, TNF-, and IL-6 contribute directly to insulin resistance through serine phosphorylation of IRS-1, impair vascular endothelial function through suppression of endothelial nitric oxide synthase (eNOS) activity, and accelerate the progression of macrovascular disease through promotion of atherogenic lipid modification, foam cell formation, and plaque instability
