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At present, existing FDA approved medications are likely a better option for people seeking pharmacological support for opioid and alcohol use disorders

For context, the fat-mass reductions reported in Billon 2024 roughly 25-30% in diet-induced obese mice over 28 days without exercise are large for a preclinical metabolic agent and explain why the "exercise mimetic" label stuck

Certain individuals may experience powerful hunger reduction and fat loss with smaller doses, while others require increased dosages to witness the same effect

For decades, the dominant clinical paradigm treated low testosterone as a symptomatic complaint to be addressed with straightforward replacement, the same way a physician might replace a deficient thyroid hormone