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Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility In mice and rats, standard two-year carcinogenicity studies with insulin glargine were performed at doses up to 0.455 mg/kg, which was for the rat approximately 65 times the recommended human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day)

Common sites for transdermal medication delivery include the upper outer arm, upper chest, upper back between the shoulder blades, and the abdomen (avoiding the waistline)

[DOI] [PMC free article] [PubMed] [Google Scholar] 221.Lutz T.A

Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials