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Owing to its high surface area and metabolic activity, trabecular bone is highly sensitive to rapid hormonal and nutritional fluctuations, making it initially more susceptible to CR-induced remodeling alterations
The accumulation of data from ensuing observational studies did not establish a direct causal relation between DM and AF, although it strengthened the notion that DM is an independent determinant for AF development [9,10,11,12]
doi: 10.1007/s00125-007-0692-2
