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As of April 2026, retatrutide is understood to be progressing through Phase 3 clinical trials large-scale studies designed to confirm efficacy and safety before a medicine can be submitted for regulatory approval

The participants had a mean baseline eGFR of 43 ml/min per 1.73 m 2 , and the slope of eGFR decline from baseline to 30 months was 2.86 ml/min per 1.73 m 2 for dapagliflozin and 3.79 ml/min per 1.73 m 2 per year for placebo, resulting in a between-group difference of 0.93 ml/min per 1.73 m 2 per year (95% CI 0.611.25)

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Media inquiries for the embargoed study are directed through JAMA Network communications, with the corresponding author listed as Michael J