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Description
Type 2 muscle fibers (fast twitch) have greater sensitivity to ACh than their type 1 counterparts translating to a larger safety factor in NMT

During the titration phase, you may notice appetite reduction before reaching your maintenance dose, with most patients experiencing maximum hunger suppression at their target dose level

GLP-1Rmediated activation of the cAMP/PKA and PI3K/Akt pathways inhibits NF-B, and thus reduces expression of proinflammatory cytokines such as TNF-, IL-1, and IL-6 (79)

Krauss.