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Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]

However, the mid-2010s ushered in a more inclusive era of body positivity

Drugs like semaglutide , tirzepatide , and retatrutide work by mimicking the GLP-1 hormone, which enhances insulin release, reduces glucagon secretion, slows stomach emptying, and communicates satiety to the brain

Napolitano A, Miller S, Nicholls AW, Baker D, Van Horn S, Thomas E, Rajpal D, Spivak A, Brown JR, Nunez DJ, Zhu Z