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Sample size estimation was based on a previous clinical trial, 11 in which the within-subject variance of log (AUC 0300 min ) for acetaminophen was estimated to be 0.03 and the between-subject variance, 0.04

Frias et al., Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial, Lancet Lond

The dual action of Tirzepatide effectively reduces caloric intake while improving glucose metabolism, which explains why the SURMOUNT-1 trial data showed up to a 22.5% mean weight reduction at the 72-week mark