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Researchers are still theorizing regarding why diarrhea happens in some people, and no definitive answer is available at this point

J Clin Transl Endocrinol 2024;35:100333

Because it targets only one receptor, microdosing is relatively straightforward

Systemic administration of fluorescently labeled tirzepatide in rodents resulted in labeling of the median eminence, area postrema, and other circumventricular organs in the brain, indicating one route of how tirzepatide may access parts of the brain to exert its effects [67]