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But there is a floor below which your body interprets caloric restriction as starvation and responds by slowing metabolism, increasing cortisol, breaking down muscle, and triggering intense fatigue

The eighth study concerned Exendin-4 treatment following nerve crush injury [26]

Annu Rev Biophys

Chronic stress elevates cortisol, which promotes fat storage (especially visceral belly fat) and interferes with fat loss even when youre in a calorie deficit