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However, how much relative GIPR to GLP-1R agonism is optimal, and whether biased agonism is rending a unique virtue to the clinical efficacy of tirzepatide are challenging, but tractable, questions requiring additional study

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Just 2% of adults on Mississippi Medicaid who meet the weight-related criteria had been prescribed a GLP-1 as of December 2024, according to a report to the states Medicaid Drug Utilization Review Board