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The complex was subjected to size-exclusion chromatography (SEC) on a Superose 6 Increase 10/300 column (GE Healthcare) equilibrated with 20 mM HEPES pH 7.5, 100 mM NaCl, 2 mM MgCl 2 , 1 M semaglutide, 0.01% (w/v) LMNG, and 0.006% (w/v) CHS

Tirzepatide produced greater average weight and waist reduction, while gastrointestinal adverse events were most common with both medications and were generally mild to moderate

Its about understanding that weight loss alone is not the same as metabolic health especially in midlife

By week 8, most patients have lost 510 pounds and notice clearer changes in how clothes fit and energy levels improve