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37 The SUMMIT trial provides further evidence of the usefulness of GLP-1RAs in HF

Gonadal steroids can also influence GLP-1R expression in the brain and other tissuesin the whole hypothalamus, for example, the highest GLP-1R expression is found in the late proestrus stage (46), providing further mechanistic support for potentially higher sensitivity to GLP-1 effects during this phase of the cycle (33, 47)

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Meanwhile, in the latest animal studies, some researchers found that exendin-4 can reduce levels of serum VLDL cholesterol and low-density lipoprotein cholesterol (LDL-C) by reducing liver sterol regulatory element binding protein 2 (SREBP2) level and cholesterol absorption [75]