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Description
The least square mean (LSM) change in HbA1c from baseline at week 52 was 2.4%, 2.6% and 2.8% with tirzepatide 5 mg, 10 mg, and 15 mg, respectively, versus 1.3% with dulaglutide
Limitations Not yet FDA-approved (as of 2025)
An exploratory mediation analysis of the effects on kidney outcomes (composite of macroalbuminuria, decreased GFR, renal death) with liraglutide and semaglutide in patients with T2DM in the LEADER and SUSTAIN-6 trials observed that HbA1c mediated 2526% and SBP 922% of kidney effects with a negligible contribution of the other parameters studied, such as body weight [15]
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