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Similar to GIP, the stimulatory effects of GLP-1 on insulin expression and secretion were observed in the presence of high (450 mg/dL) but not normal (99 mg/dL) concentrations of glucose in the cultured cells, indicating the glucose-dependent insulinotropic effect of GLP-1 (117)

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position 8, where alanine is substituted by alpha-aminoisobutyric acid and thus increasing resistance to DPP-4 degradation, position 34, where lysine is changed by arginine and thus, preventing wrong binding of C-18 fatty acid, and position 26, where lysine is a acylated with a glutamate spacer 15 to provide specific binding to albumin

Unfortunately, the occurrence of some adverse events has caused deep concern about the long-term safety of GLP-1RAs