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Description
We report herein a series of pharmacological and molecular studies in two validated mouse models of PCOS, generated by gestational (PNA) or postweaning (PWA) androgenization, addressing the effects of GLP1-based multi-agonist therapies on metabolic and reproductive traits of PCOS

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

Whilst moderate dehydration doesnt directly impact the effectiveness of the medication, severe dehydration could potentially affect overall metabolism and medication absorption

Although, most participants lost weight, there was heterogenicity, that has been well-documented in obesity studies [66] and those with higher BMI above 35 experienced greater mean percentage weight loss [64]