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It has therefore been considered suboptimal when evaluating treatment effects in clinical trials [71, 72]

Investigation of the safety and efficacy profile of semaglutide and tirzepatide used in patients with T1D who have previously undergone allogeneic islet transplantation/pancreas transplantation and/or kidney transplantation for improving glucose control, reducing beta-cell glucotoxicity, mitigating the immunosuppressant-induced beta-cell dysfunction [152], preserving endogenous insulin secretion, preventing graft dysfunction and graft failure, promoting graft function and survival, and possibly reducing the required doses of immunosuppressants through anti-hyperglycemic actions and potential anti-inflammatory, antioxidant, immunomodulatory and beta-cell protective properties (stimulation of beta-cell proliferation and survival)

As obesity continues to place a major burden on health systems, medications that can improve health outcomes while simultaneously decreasing the cost of healthcare may influence future healthcare policy and population health

And so those are your two ingredients