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A pilot study reported that a combination of exenatide and nicotine replacement therapy improved smoking abstinence rates, reduced withdrawal symptoms, and alleviated post-cessation weight gain

Many people experience side effects like nausea, constipation, or fatigue early on, though these often ease as the body adjusts to the medication

The medications effectiveness is measured by weight reduction, A1C improvement, and appetite suppression not by cardiovascular side effects
