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Figure 1 Statements Author contributions JC, AM, YW, CL, HQ, XM, HY, and LD searched the data, JC, XR, and JZ wrote the main manuscript text

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Lipid mediators are critical in resolving inflammation: a review of the emerging roles of eicosanoids in diabetes mellitus

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Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)

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doi:10.1016/j.bbrc.2013.12.049 114

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