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Efficacy and safety of Glucagon-Like Peptide-1 receptor agonists on body weight and cardiometabolic parameters in individuals with obesity and without diabetes: a systematic review and meta-analysis

Some of it - sometimes a meaningful chunk of it - comes from lean muscle tissue
In a direct obesity trial, tirzepatide produced greater average weight loss, but both commonly caused gastrointestinal side effects

You might need to get plugged in with a dietitian to make sure you have good nutrition. And while you might be used to talking with your doctor about diet and exercise, remember that other healthy habits support your weight loss goals
