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Furthermore, direct comparisons of GLP-1RAs and exercise in diverse populations are scarce, and evidence on optimal sequencing, duration, and integration of hybrid interventions remains limited ( Beyond physiological adaptations, treatment adherence and long-term success largely depend on motivation, self-efficacy, and body-image perception, which may fluctuate during pharmacologic weight loss (63)

Most patients tolerate this frequency well, experiencing gradual appetite suppression and improved metabolic function

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A study investigated whether weight loss was sustained better one year after termination of a GLP-1, supervised exercise program, or combined for one year (4)