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Future challenges: Advancements have been made, but some key issues still remain

Lillys oral GLP-1, orforglipron, demonstrated statistically significant efficacy results and a safety profile consistent with injectable GLP-1 medicines in successful Phase 3 trial | Eli Lilly and Company [Internet]
CNS/GI Medications : Opioids and anticholinergics can worsen GI side effects, while timing adjustments may be needed for some antidepressants or corticosteroids
