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In patients with obesity (mean age 51.3 years, 65.6% women), semaglutide compared with non-GLP-1RA anti-obesity medications was associated with lower risk for incident CUD in patients with no prior history CUD (HR: 0.56, 95% CI: 0.420.75), and recurrent CUD diagnosis in patients with a prior history CUD (HR: 0.62, 95% CI: 0.460.84)

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However, tirzepatide targets GLP-1 as well as GIP receptors, which is why it may have more gastrointestinal side effects such as nausea and diarrheafor this reason, some people find semaglutide easier to handle if they're sensitive to GIP effects

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Its always important to set realistic expectations, as results are not guaranteed

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Patients with a history of pancreatitis should be evaluated carefully before initiating treatment with Semaglutide / Cyanocobalamin Injection, as GLP-1 receptor agonists have been associated with acute pancreatitis in post-marketing surveillance, though a definitive causal relationship has not been established

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