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Data availability The datasets from this study are not publicly accessible due to national data protection regulations and ethical restrictions designed to protect participant privacy

[55] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake

While Retatrutide naturally reduces caloric intake through appetite suppression, deliberately eating too little accelerates muscle loss even with anabolic support

Tirzepatide (weekly dual GIP + GLP-1 agonist