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Studies in metabolic disease consistently report elevated systemic LPS levels associated with dysbiosis and metabolic endotoxemia (Dong et al., 2022), and these increases correlate with -cell transcriptional stress signatures observed in scRNA-seq analyses, including the expansion of ATF4 + and XBP1 + subclusters and the downregulation of maturity-related transcription factors such as PDX1 and MAFA under inflammatory conditions (Sokolowski et al., 2024)

Zepbound received FDA approval in November 2023 as a weight-management injectable and follows controlled manufacturing, stability testing, and quality assurance protocols

These produce and send out calcitonin, which is important for calcium homeostasis, an essential process for bone health and nerve function

10.1016/j.cellsig.2024.111088 [DOI] [PubMed] [Google Scholar] Wang M., Liu M., Zheng J., Xiong L., Wang P