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While not a formal contraindication, clinicians generally defer initiation of tirzepatide until patients with hyperthyroidism are euthyroid, as overlapping symptoms and cardiovascular effects could complicate assessment of medication tolerance and efficacy

We offer guidance on this as part of our comprehensive care, which you can read about in our nutrition philosophy

The alternation typically resolves as your system finds a new equilibrium, usually within the first 8 to 12 weeks of stable dosing

Finding a way to increase the biological half-life of GLP-1 or using GLP-1 analogs could be a step in the right direction to expand the treatment options for UC