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Soykan et al

In particular, glucagon has firmly been demonstrated to enhance hepatic lipid metabolism, Hepatic GCGR agonism leads to upregulation of lipid catabolism pathways in the hepatocyte where a number of key regulatory transporters and enzymes facilitate beta oxidation of fatty acids (61)
Have previously been unsuccessful with traditional methods of weight loss, like diet and exercise

They slow gastric emptying, change bile acid composition, and affect the gut microbiome
