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The science, as its described, is transdermal delivery
Affinity pull-down and mass spectrometric (MS) analyses consistently identified MTP (also known as HADHA) as the main interacting binding partner for GLP-1(2836)
Diabetes Care 24:489494 Green BD, Irwin N, Duffy NA, Gault VA, OHarte FP, Flatt PR (2006) Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
