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Beyond those primary effects, berberine has shown favorable results on inflammatory markers including CRP and IL-6, and emerging research points to gut microbiome benefits berberine appears to shift bacterial composition toward strains associated with metabolic health
It means the appetite and weight changes are real

Hazard ratios derived from CVOT populations, often comprising people with prior cardiovascular disease or high cardiovascular risk, may also not be applicable to more general populations with type 2 diabetes [48, 50]
