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Central nervous system effects also likely contribute to the therapeutic profile of incretin-based medications

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The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16

Whilst photosensitivity is not a recognised side effect of Rybelsus, patients with diabetes should maintain good sun safety practices year-round