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FIB-4 demonstrates a high negative predictive value (NPV 90%) for excluding advanced fibrosis, supporting its role as an effective first-line screening tool

This included significant reductions in the incidence of CV death, nonfatal myocardial infarction and nonfatal stroke (Lincoff et al, 2023)

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Rare but important risks include pancreatitis, gallbladder problems, dehydration from severe vomiting/diarrhoea, and potential worsening of diabetic eye disease in people with diabetes