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Conclusions By recruiting participants with shared disease exposures, the TRIUMPH program will assess the safety and efficacy of retatrutide for the treatment of adults with obesity and two of its common complicationsOSA and OA

Additionally, we discuss the effects and mechanism of various interventions, such as prebiotics, probiotics, antidiabetic drugs, and bariatric surgery, on the crosstalk between gut microbiota and GLP-1

Lipid Metabolism In the SURPASS and SURMOUNT phase 3 clinical trial programs (Tables 1 and 2), treatment with tirzepatide was related to an improvement in the lipid profile, with major decreases in triglycerides (Table 4) that cannot be fully accounted for by reductions in weight alone [77]

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