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Description
In addition to acting on GLP-1 receptors, tirzepatide also targets GIP receptors located in the pancreas, adipose (fat) tissue, and brain regions involved in eating behavior and insulin regulation
Pharmacy Benefit Managers (PBMs) are playing a crucial role by negotiating hefty rebates with manufacturers in exchange for formulary placement
JAMA Neurol 76(4):420429 Brown JC, Dryburgh JR (1971) A gastric inhibitory polypeptide II: the complete amino acid sequence
This unique combination allows for enhanced metabolic effects that go beyond what is seen with current GLP-1-only medications
