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Jastreboff, MD, PhD, director of the Yale Obesity Research Center, said in a statement

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In the STZ+Sm group, the ventricular edge was partially bordered by intact ependymocytes (not forming a dense layer) and vimentin-positive cells lacking the characteristic elongated basal processes of tanycytes, suggesting remodeling of the ventricular marginal layer by scar-forming, vimentine expressing astroglia or reactive ependymal changes (Fig

Therefore, we used a conservative uniform distribution to represent the potential range of risk reduction, as this distribution reasonably reflects the possible interval of risk reduction effect in the absence of precise data