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By the end of week four, most patients beginning semaglutide therapy see measurable weight loss of 36 pounds, assuming consistent adherence and no major dietary changes in the opposite direction

Patient education should address proper injection technique, site selection (abdomen, thigh, or upper arm), and recognition of injection site reactions

NHS treatment includes specific stopping rules (minimum weight loss thresholds at review points) and typically has a maximum treatment duration of 2 years

The medication's effects on insulin sensitivity and modest weight loss often lead to resumption of ovulation and regular cycles within 3-6 months