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Description
First, it increases caloric needs that may be difficult to meet given suppressed appetite
At 24 weeks, mean percentage decrease in weight (primary outcome) ranged from 7.2% to 17.5% with different retatrutide doses compared with 1.6% with placebo
At 48 weeks, 100% of participants on the 8 mg and 12 mg doses had achieved at least 5% weight loss (Jastreboff et al., NEJM , 2023)
In the GLP-1 era, that is more important than ever
