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Without exercise to keep your metabolism active, the gap between calories consumed and burned shrinks, which can slow down or stall weight loss

The GLP1R rs6923761 variant determines your individual GLP-1 receptor sensitivity, helping predict whether you'll need lower or higher doses for weight loss benefit

Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g

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