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Once inserted at the correct angle and depth, pause for one second before depressing the plunger to allow tissue accommodation

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Additionally, the FDA recommends that these medications not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because studies in rats, rabbits, and monkeys demonstrated that animals treated with these medications had higher rates of miscarriage, were born smaller, and were more likely to have birth defects

This is a perfect example of nature-inspired biology
