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Use only under medical supervision

Its FDA approved for long-term weight management in adults with obesity and for those who are overweight with a related health condition, such as high blood pressure

Indeed, deletion of Acvr2a and Acvr2b in muscle cells protects against weight gain in response to high-fat diet feeding, demonstrating that loss of ActRII signaling in myofibers can indirectly influence fat accumulation [30]