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This regulatory effect is partly mediated via the AMPK/sirtuin-1 (SIRT1) axis, as knockdown of SIRT1 abrogated the lipid-lowering and autophagy-inducing effects of GLP-1RAs, highlighting a crucial role of this pathway in regulating lipid metabolism by facilitating degradation of lipid droplets, thus preventing excessive lipid accumulation (12)
Further, active forms of GLP-1, as well as inactive metabolites, are rapidly eliminated by the kidneys (11, 13)
Understanding side effects GLP-1 analogs can cause side effects that mimic digestive issues that are common in IBD patients

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