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The multiple-dose regimen, given for up to 4 weeks, led to a dose-dependent weight loss between 2.87 and 5.46 kg, compared to 2.37 kg for placebo

Recently, it has been demonstrated that binge-like eating over several weeks in a model of intermittent fat feeding in rats affects the GLP-1 system, decreasing PPG mRNA expression in the NTS, suggesting downregulation of central GLP-1 signaling [265], accordingly with dysfunction in satiation processes that generally serve to limit food intake observed in different animal models [265]

Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation

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