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GLP-1 and exendin-4 enhance differentiation and neurite outgrowth in rat pheochromocytoma (PC12) cells and in human neuroblastoma SK-N-SH cells [825]
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These specific effects can impact the therapeutic use of individual DPP4is and probably elucidate offtarget adverse reactions, including hospitalization for heart failure, that are observed only with saxagliptin [156]
doi: 10.1210/en.2003-0007
