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Additionally, HDL exerts anti-inflammatory and antioxidant effects, stabilizing vascular endothelium and mitigating plaque instability, both critical factors in reducing CV events [69,70,71]

Novo Nordisks Wegovy, for example, recently showed a 20% reduction to incidence of heart attack, stroke, or death from heart disease

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While the mechanisms responsible for these potent effects remain incompletely understood, contributors include altered postprandial nutrient delivery to the intestine, increased secretion of glucagon-like peptide 1 (GLP-1) by intestinal L cells, increased insulin secretion, intestinal mucosal adaptations, alterations in the gut-brain axis, and changes in bile acid content and composition (3, 4)