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revealed that individuals carrying the A1AT PiZ variant in a heterozygous state face a more than sevenfold higher risk of developing cirrhosis in MASLD
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Previous study showed that body weight loss could improve HRQOL

Clin Pharmacol Ther 88:801808 Napolitano A, Miller S, Nicholls AW et al (2014) Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus

Both high fat and carbohydrate diets impair vagal activity and disrupt satiety regulation (Loper et al