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Patients in Hathaway et al.s study were recruited from a neuro-ophthalmology clinic at a tertiary care institute who very likely have significant underlying symptoms and neuro-ophthalmic diseases that distinctly differ from those of the general population taking GLP-1RAs, potentially causing a selection bias, they wrote

You should contact your GP if you experience any of the following: Severe or worsening cold intolerance : If you feel persistently cold despite appropriate clothing and environmental adjustments, or if the symptom progressively worsens, this may indicate an underlying issue requiring investigation

This finding was consistent with the fact that ghrelin preadministration reduced GLP-1-induced Fos expression in the NTS when administered at a 30-min interval but not at a 60-min interval

Some private and commercial insurance plans might cover certain weight loss medications, while others might not, and some may require prior authorization for coverage