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In similar experiments in another transgenic animal model, overexpressing human islet amyloid polypeptide did not reveal any ductal abnormalities (histology) or a change in ductal cell proliferation rates with sitagliptin, metformin, sitagliptin with metformin, or placebo treatment (15)
You cant just, taking a pill or placebo is pretty easy

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doi: 10.1016/j.neuropharm.2014.04.007 19 XuMWuHYLiuHGongNWangYRWangYX