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Under the framework applied here, gastrin would be classified as a failed target rather than an underexplored one, because its abandonment followed rigorous human evaluation

[DOI] [PubMed] [Google Scholar] 36.Irwin DM
Both native glucagon and GCGR-GLP-1R co-agonists acutely increase energy expenditure in short-term studies over hours to days in humans [[54], [55], [56], [57]]

Knudsen saw attaching a fatty acid to the peptide as means to prevent its digestion by enzymes in the body
