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Changes in Facial Appearance: While some individuals may like the appearance of decreased facial fullness, this can cause the skin to sag and appear older

Both injectable options come with pens that are relatively easy to self-inject at home

Water retention patterns, appetite changes, and metabolic rate fluctuations tied to the menstrual cycle can create a less smooth weight loss curve

Collectively, reviews place the proportion of lean mass in total weight loss at ~15% to 40% (or higher in select settings), reflecting differences in drug, dose, baseline composition, and duration
