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The observation that IV GLP-1 leads to a reduction in plasma glucose after a meal in individuals with T2D, while a rise in plasma glucose was observed after subsequent meals (18), suggested there may be tachyphylaxis for the effects of GLP-1 to slow gastric emptying

however, comparative studies indicate that continuous positive airway pressure (CPAP) remains significantly more effective than liraglutide when used as monotherapy.[45] Two recent randomized controlled trials involving 469 participants without diabetes and with moderate to severe OSA demonstrated a 55% reduction in AHI with tirzepatide treatment.[17] These findings led to FDA approval of tirzepatide for moderate to severe OSA in December 2024

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