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Retatrutide is initiated at a low dose and gradually increased over several months to minimise gastrointestinal side effects such as nausea, vomiting, and diarrhoea

However, rapid weight loss with semaglutide can lead to loss of lean muscle mass

These findings suggest that liraglutide specifically reduces bone resorption without influencing bone formation.368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption.369,370 Genetic disruption of GLP-1R signaling leads to cortical osteopenia and heightened bone fragility, primarily caused by increased bone resorption by osteoclasts

This underscores that these medications are chronic therapies similar to how antihypertensives or statins are long-term